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BIO502 : Genomics

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Post Doctorate
WHO-IARC, Lyon, France

Course Contents

Genetics and sub-disciplines, Terminologies and laws used in genetic and inheritance concepts. Polygenic traits, Epistasis and Pleiotropy.  Environmental effect on Euchromatin and Heterochromatin.  Chromatin, Chromatin Folding, Sex Chromosomes and Sex determination, Salient features of DNA and Nucleotides. DNA Chargaff Rule, Cell Cycle, Multiple Alleles, Correlation of Alleles and Genotypes   and Polygenic Inheritance in genetics. Epistasis and their types, Epigenetics, Chromosome Location and Common Numerical Abnormalities like Trisomy, Polyploidy, Alloploidy. Structural Abnormalities, Patterns of genetic disorders & RNA Splicing. Function, Structural, Comparative Genomics. Genome sequencing and its benefits in research. Genes and sizes of genomes.

What is genetics     
2Sub discipilines of Genetics     
3Genetics Terminologies     
4Mendel s’ law of Dominance     
5Monohybrid Cross and Dihybrid Cross     
6Mendel s’ law of Segregations     
7Mendel s’ law of Independent Assortment     
8Modern Genetics Concepts     
10Mendelian and Non-Mendelian Inheritance     
11Conclusions of Mendelian Inheritance     
12Exceptions to Mendelian Inheritance     
13Incomplete Dominance     
15Polygenic traits     
18Environmental Effects     
19Euchromatin and Heterochromatin     
20Staining and Banding Chromosomes     
22Chromatin and Chromosomes     
23Higher Order Chromatin Folding     
26Prokaryotic Chromosomes     
27Sex Chromosomes and Sex determination     
28Salient features of DNA     
29Nucleotides – building blocks of DNA     
30Conformations of DNA     
31Chargaff Rule of Base Ratio     
32Cell Cycle     
33Summary - Mitosis and Meiosis     
34Concept of Multiple Alleles     
35Multiple Alleles - our blood group     
36Blood groups and Transfusions     
37Multiple alleles effect in rabbits     
38Correlation of Alleles and Genotypes     
39Polygenic Inheritance     
40Examples of Polygenic inheritance     
41What is Epistasis     
42Types of Epistasis     
43What is Epigenetics     
44Epigenetic Modifications     
45Chromosomal Aberrations     
46Karyotyping- international description     
47Defining Chromosome Location     
48Common Numerical Abnormalities     
54Polyploidy and Aneuploidy     
55Structural Abnormalities     
57Chromosomal Deletions     
58Chromosomal duplication     
59Chromosomal Inversions     
60Inheritance Patterns of Genetic Disorders     
61Autosomal Recessive Inheritance     
62Autosomal Dominant Inheritance     
63X-linked recessive inheritance     
64X-linked dominant inheritance     
65Maternal inheritance of mt DNA     
66Polymerases I and III     
67Polymerases I and III (Conti...)     
68RNA Splicing     
69How splicing site is determined     
70Removal on Introns     
71The Spliceosome     
72The Splicing Pathway     
73Self-Splicing Introns     
74Group I Introns     
75Finding the Splice Sites Correctly     
76Introduction to genomics     
77Functional Genomics     
78Structural genomics     
79Comparative genomics     
80Population Genomics     
82Genetics and Genomics     
83Genomics, Proteomics and metabolomics     
84Why sequence genomes     
85Genome characterization-technique used     
86Genome analysis steps     
87Benefits of Genomes research     
88Genes and Sizes of Genomes     
89Viral Genomes     
90Bacterial genomes     
91Yeast genome     
92Mitochondrial genome     
93Chloroplast genome (cpDNA)     
94Eukaryotic genomes     
95Genomes Comparison     
96Comparing distantly and closely related species     
97Anatomy and organization of genome     
98Gene anatomy     
99Prokaryotic gene and eukaryotic gene     
100Types of eukaryotic DNA     
101Duplicated genes and Pseudo genes     
102Repetitive DNA     
103Mobile DNA     
104Movement of transposons and retrotransposons     
105Transposons in Prokaryotes and Eukaryotes     
106Long terminal repeats     
107LINE and SINES     
108Genetic Variations     
109Gene families and Gene clusters     
110Types of Proteins and families     
111Gene densities     
112Genome evolution     
113Molecular Phylogenetic Analysis     
114Genes tree and species tree     
115Mitochondrial Genome Evolution     
116Genome evolution – Nucleotide substitution     
117Genome evolution CpG mutation rate     
118Genome evolution – Indels     
119Genome evolution Gene conversion     
120Genome evolution-Gene Duplications     
121Genome Evolution Exons Shuffling and duplications     
122Genome evolution – Recombination hotspots     
123Genome evolution double stranded break repair     
124Genome evolution chromosomal rearrangements     
125Gene expression mechanisms     
126Gene expression and gene switches     
127inducible and repressible sysytems     
128Regulation of gene expression in prokaryortes     
129Operon Model of prokaryotes     
130Eukaryotic gene expression     
131Control of gene expression in Eukaryotes     
132Cis acting elements     
133Trans acting elements     
134Gene expression and RNA interference     
135Prokaryotic and Eukaryotic Expression difference     
136Genome mapping     
137Genetic mapping of the Genomes     
138Genetic Markers     
139Characteristics of the genetic markers     
140DNA markers     
141Applications of Molecular markers     
142Physical mapping of the genome     
143Cytogenic mapping     
144FISH mapping     
145Restriction mapping of the genoome     
146Radiation hybrid mapping of the genome     
147Clone contig mapping of the genome     
148Generating Sequence of the genomes     
149Human Genome Project     
150Human Genome Project- Hierarchical Short Gun sequencing approach     
151Human Genome Project- Whole Genome Short Gun sequencing approach     
152Characteristics of our Genome part 1     
153Characteristics of our Genome part 2     
154Gene Functions     
155Genome Browsers UCSC     
156Genome Browsers ENSEMBLE     
157The hap map project     
158the 1000 genomes     
159HGP ethical and legal issues     
160HGPfuture challenges     
161Genome annotations Protein coding genes     
162genome annotations : transcription factors     
163Genes predictions in prokaryotes     
164Gene Predictions in Eukaryotes     
165Arabidopsis Genome     
166Mouse genome     
167Comparison between mouse and human genome     
168Proteomics Types and Techniques     
169Characteristics of Human Proteome     
171Mapping of disease genes     
172Type of linkage analysis     
173Genome wide association studies     
174Association studies vs linkage studies     
176Types of microarray     
177Microarray Formats     
180Microarray – Applications     
181Types of RNA and RNomics     
182Non coding DNA     
183Non coding RNAs     
185Biogenesis of miRNA     
186Functions of miRNA     
187Mode of action miRNA     
188Non coding RNA and X chromosome Silencing     
189RNA Induced Silencing Complex     
191Dicer and Drosha     
192Design of siRNA     
193Applications of siRNA     
196Small ribozymes and riboswitches     
197Pharmacogenetics and Pharmacogenomics     
198Pharmacogenomics principles and potentials     
199Study of Omics