Course Overview
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Course Synopsis
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This course of Genomics is divided into two basic areas: structural genomics, characterizing the physical nature of whole genomes; and functional genomics, characterizing the transcriptome (the entire range of transcripts produced by a given organism) and the proteome (the entire array of encoded proteins).
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Course Learning Outcomes
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Basic and General Genomics
- Students who are pursuing this course of genomics will enable themselves to grab the concept of basic and general genomics, in which students learn about the structural genomics, characterizing the physical nature of whole genomes; and functional genomics, characterizing the transcriptome. Other potential topics in the curriculum include a proteome (the entire array of encoded proteins).
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Course Calendar
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Week 01
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2
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Sub discipilines of Genetics
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4
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Mendel s’ law of Dominance
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5
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Monohybrid Cross and Dihybrid Cross
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6
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Mendel s’ law of Segregations
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7
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Mendel s’ law of Independent Assortment
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8
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Modern Genetics Concepts
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10
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Mendelian and Non-Mendelian Inheritance
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11
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Conclusions of Mendelian Inheritance
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12
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Exceptions to Mendelian Inheritance
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Week 02
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19
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Euchromatin and Heterochromatin
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20
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Staining and Banding Chromosomes
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22
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Chromatin and Chromosomes
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23
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Higher Order Chromatin Folding
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26
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Prokaryotic Chromosomes
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27
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Sex Chromosomes and Sex determination
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28
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Salient features of DNA
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29
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Nucleotides – building blocks of DNA
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Week 03
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31
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Chargaff Rule of Base Ratio
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33
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Summary - Mitosis and Meiosis
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34
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Concept of Multiple Alleles
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35
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Multiple Alleles - our blood group
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36
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Blood groups and Transfusions
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37
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Multiple alleles effect in rabbits
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38
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Correlation of Alleles and Genotypes
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40
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Examples of Polygenic inheritance
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44
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Epigenetic Modifications
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Week 04
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45
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Chromosomal Aberrations
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46
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Karyotyping- international description
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47
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Defining Chromosome Location
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48
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Common Numerical Abnormalities
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54
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Polyploidy and Aneuploidy
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55
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Structural Abnormalities
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58
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Chromosomal duplication
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59
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Chromosomal Inversions
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60
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Inheritance Patterns of Genetic Disorders
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Week 05
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61
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Autosomal Recessive Inheritance
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62
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Autosomal Dominant Inheritance
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63
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X-linked recessive inheritance
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64
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X-linked dominant inheritance
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65
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Maternal inheritance of mt DNA
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67
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Polymerases I and III (Conti...)
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69
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How splicing site is determined
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Week 06
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75
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Finding the Splice Sites Correctly
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76
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Introduction to genomics
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83
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Genomics, Proteomics and metabolomics
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85
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Genome characterization-technique used
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87
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Benefits of Genomes research
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88
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Genes and Sizes of Genomes
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Week 07
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93
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Chloroplast genome (cpDNA)
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96
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Comparing distantly and closely related species
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97
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Anatomy and organization of genome
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99
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Prokaryotic gene and eukaryotic gene
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100
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Types of eukaryotic DNA
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101
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Duplicated genes and Pseudo genes
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Week 08
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104
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Movement of transposons and retrotransposons
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105
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Transposons in Prokaryotes and Eukaryotes
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106
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Long terminal repeats
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109
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Gene families and Gene clusters
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110
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Types of Proteins and families
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113
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Molecular Phylogenetic Analysis
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114
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Genes tree and species tree
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115
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Mitochondrial Genome Evolution
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116
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Genome evolution – Nucleotide substitution
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Week 09
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117
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Genome evolution CpG mutation rate
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118
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Genome evolution – Indels
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119
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Genome evolution Gene conversion
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120
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Genome evolution-Gene Duplications
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121
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Genome Evolution Exons Shuffling and duplications
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122
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Genome evolution – Recombination hotspots
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123
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Genome evolution double stranded break repair
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124
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Genome evolution chromosomal rearrangements
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125
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Gene expression mechanisms
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126
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Gene expression and gene switches
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127
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inducible and repressible sysytems
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128
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Regulation of gene expression in prokaryortes
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129
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Operon Model of prokaryotes
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130
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Eukaryotic gene expression
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Week 10
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131
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Control of gene expression in Eukaryotes
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133
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Trans acting elements
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134
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Gene expression and RNA interference
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Week 11
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135
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Prokaryotic and Eukaryotic Expression difference
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137
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Genetic mapping of the Genomes
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139
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Characteristics of the genetic markers
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141
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Applications of Molecular markers
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142
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Physical mapping of the genome
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145
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Restriction mapping of the genoome
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146
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Radiation hybrid mapping of the genome
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147
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Clone contig mapping of the genome
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148
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Generating Sequence of the genomes
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Week 12
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150
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Human Genome Project- Hierarchical Short Gun sequencing approach
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151
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Human Genome Project- Whole Genome Short Gun sequencing approach
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152
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Characteristics of our Genome part 1
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153
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Characteristics of our Genome part 2
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156
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Genome Browsers ENSEMBLE
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159
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HGP ethical and legal issues
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161
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Genome annotations Protein coding genes
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162
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genome annotations : transcription factors
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163
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Genes predictions in prokaryotes
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164
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Gene Predictions in Eukaryotes
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Week 13
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167
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Comparison between mouse and human genome
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168
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Proteomics Types and Techniques
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169
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Characteristics of Human Proteome
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171
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Mapping of disease genes
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172
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Type of linkage analysis
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173
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Genome wide association studies
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174
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Association studies vs linkage studies
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180
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Microarray – Applications
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181
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Types of RNA and RNomics
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Week 14
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188
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Non coding RNA and X chromosome Silencing
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189
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RNA Induced Silencing Complex
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193
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Applications of siRNA
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196
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Small ribozymes and riboswitches
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197
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Pharmacogenetics and Pharmacogenomics
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198
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Pharmacogenomics principles and potentials
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