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BT732 : Genetics & Genomics

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Course Info

Course Category

Biotechnology

Course Level

Graduate

Credit Hours

3

Pre-requisites

N/A

Instructor

Prof. Dr. Jamil Ahmad
PhD, Post Doc
University of the Punjab, WHO-IARC, Lyon, France

Course Contents

Introduction to genetics, Mendel s’ law of Dominance, laws of genetics, Importance of Genetics, Types and source of Variation, Mendelian work and conclusion, What are Chromosomes, Cell, Nucleus and Chromosome, Chromosome Numbers in Different Species, Introduction to chromosomes and its types, Salient features of DNA, introduction to cell , Cell Division, Cell Cycle, Concept of Multiple Alleles, chromosomal Abnormalities  and variations. Mutation types and effects. Introduction to genomics, Genome characterization-technique used ,Genes and Sizes of Genomes, Gene anatomy, Genetic Variations, Genome evolution ,  Gene expression mechanisms and controlling factors, Cis-acting elements, Trans-acting elements, Gene expression and RNA interference. Prokaryotic and eukaryotic gene expression –difference, Genetic mapping of genomes. Genetic markers and applications, Mapping of genomes; Physical, Cytogenetic, FISH, Restrictions, Radiation hybrid, Clone contigs. Generating sequence of genomes and Human Genome project. Human genome Characteristics. Genome browsers and HapMap project.  Ethical, legal issues and Future Challenges of human genome project. Proteins coding genes and Genome annotation – transcription factors.  Gene predictions in Prokaryotes and Eukaryotes, Arabidopsis,  Mouse and Comparison with human genome.  Proteomics Types and Techniques. Mapping of disease genes, Type of linkage analysis. Genome wide association studies and  Microarrays Procedure and Types.  RNA and RNomics, Non coding DNA and Non coding RNAs. miRNA , Biogenesis, Functions and mode of action miRNA RNA Induced Silencing Complex, siRNA Design and its Applications, Ribozymes, Metalloribozymes, Small ribozymes and riboswitches. Pharmacogenetics and Pharmacogenomics principles and potentials Study of Omics.