Course Overview
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Course Synopsis
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This is one of the course which introduces students to the fundamentals of genetic science through a basic study of the genetic material, what is the mode of inheritance, genetic and inherited diseases, concept of classical genetics, long way of Mendelian genetics to modern genetics, speciation, and evolutionary genetics, differentiation between microevolution and macroevolution. Moreover, advanced studies of genes, genomes and molecular genetics will also be touches in the later part of the course.
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Course Learning Outcomes
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Mendelian Genetics, Modern Genetics and Molecular Genetics
- classical genetics, modern genetics, types of genetics, mode of inheritances, genetics diseases, genomics, Modern research and research techniques in genetics, molecular genetics. understanding of all these topics will enable you to understand the advanced courses in general genetics, molecular biology, cell biology, recombinant DNA technology and genomics
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Course Calendar
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Week 01
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2
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Sub discipilines of Genetics
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4
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Mendel's law of Dominance
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5
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Monohybrid Cross and Dihybrid Cross
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6
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Mendel s’ law of Segregations
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7
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Mendel s’ law of Independent Assortment
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8
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Modern Genetics Concepts
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12
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Genetic and Acquired Variation
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13
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Types of Variation- Continuous and Discontinuous Variation
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15
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Heredity and Variation in Mendel s’ work
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16
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Mendelian and Non-Mendelian Inheritance
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17
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Conclusions of Mendelian Inheritance
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Week 02
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18
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Exceptions to Mendelian Inheritance
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26
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Cell, Nucleus and Chromosome
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27
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Chromosome Numbers in Different Species
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28
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Chromosomes in Prokaryotes and Eukaryotes
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29
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Salient features of Chromosomes
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34
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Euchromatin and Heterochromatin
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35
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Staining and Banding Chromosomes
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Week 03
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37
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Chromatin and Chromosomes
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38
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Higher Order Chromatin Folding
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41
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Prokaryotic Chromosomes
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42
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Sex Chromosomes and Sex determination
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43
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Salient features of DNA
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44
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Nucleotides – building blocks of DNA
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46
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Chargaff Rule of Base Ratio
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52
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Unreplicated and Replicated Chromosomes
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Week 04
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60
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Somatic cells and Gametes
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61
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Homologous Chromosomes
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65
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Metaphase I of Meiosis
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67
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Telophase I of Meiosis
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68
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Prophase II of Meiosis
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69
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Metaphase II of Meiosis
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70
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Anaphase II of Meiosis
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71
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Telophase II of Meiosis
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Week 05
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73
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Summary - Mitosis and Meiosis
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74
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Concept of Multiple Alleles
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75
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Multiple Alleles - our blood group
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76
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Blood groups and Transfusions
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77
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Multiple alleles effect in Drosophila
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78
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Correlation of Alleles and Genotypes
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80
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Examples of Polygenic inheritance
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84
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Epigenetic Modifications
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85
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Chromosomal Aberrations
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86
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Karyotyping- international description
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87
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Defining Chromosome Location
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88
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Common Numerical Abnormalities
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Week 06
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94
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Polyploidy and Aneuploidy
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95
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Structural Abnormalities
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98
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Chromosomal Insertions
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99
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Chromosomal Inversions
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102
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Somatic and Germline Mutation
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103
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Forward, Reverse and Neutral Mutation
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104
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Loss of function, Gain of function
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105
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Spontaneous and Induced Mutation
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Week 07
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114
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Mutation Nomenclature
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115
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Salient feature of Mutation Nomenclature
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116
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Mutation at DNA, RNA and Protein level
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117
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Mutation in Intronic Sequence
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118
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Specific changes in Sequence
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119
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What are Genetic Disorders
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120
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Inheritance Patterns of Genetic Disorders
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121
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Autosomal Recessive Inheritance
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122
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Autosomal Dominant Inheritance
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Week 08
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123
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X-linked recessive inheritance
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124
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X-linked dominant inheritance
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125
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Maternal inheritance of mt DNA
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126
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Introduction to genomics
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132
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Genetics and Genomics
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133
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Genomics, Proteomics and metabolomics
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135
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Genome characterization-technique used
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136
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Genome analysis steps
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137
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Benefits of Genomes research
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138
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Genes and Sizes of Genomes
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Week 09
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143
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Chloroplast genome (cpDNA)
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146
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Comparing distantly and closely related species
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147
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Anatomy and organization of genome
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149
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Prokaryotic gene and eukaryotic gene
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150
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Types of eukaryotic DNA
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151
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Duplicated genes and Pseudo genes
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154
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Movement of transposons and retrotransposons
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155
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Transposons in Prokaryotes and Eukaryotes
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156
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Long terminal repeats
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Week 10
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159
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Gene families and Gene clusters
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160
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Types of Proteins and families
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163
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Molecular Phylogenetic Analysis
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164
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Genes tree and species tree
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165
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Mitochondrial Genome Evolution
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166
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Genome evolution – Nucleotide substitution
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167
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Genome evolution CpG mutation rate
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168
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Genome evolution – Indels
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169
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Genome evolution Gene conversion
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170
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Genome evolution-Gene Duplications
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171
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Genome Evolution Exons Shuffling and duplications
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172
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Genome evolution – Recombination hotspots
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173
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Genome evolution double stranded break repair
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174
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Genome evolution chromosomal rearrangements
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175
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Gene expression mechanisms
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176
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Gene Expression and Genetic Switches
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177
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Inducible, repressible systems
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178
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Regulation of gene expression in Prokaryotes
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179
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Operon model of Prokaryotes
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Week 11
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180
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Eukaryotic gene expression
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181
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Control of gene expression in Eukaryotas
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183
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Trans-acting elements
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184
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Gene expression and RNA interference
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185
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Prokaryotic and eukaryotic gene expression -difference
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187
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Genetic mapping of genomes
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189
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Characteristics of genetic markers
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191
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Applications of molecular markers
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192
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Physical mapping of Genomes
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193
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Cytogenetic mapping of genomes
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194
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FISH mapping of genomes
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195
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Restrictions mapping of Genomes
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196
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Radiation hybrid mapping of genomes
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197
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Clone contigs mapping of genomes
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198
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Generating sequence of genomes
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Week 12
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200
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Human Genome project - Hierarchical shotgun sequencing
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201
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Human Genome project- Whole Genome shotgun sequencing
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202
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Human genome Characteristics (A)
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203
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Characteristics of our genome - B
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206
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Genome browser- Ensemble
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209
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Ethical and legal issues of Human Genome Project
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210
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Future Challenges of human genome project
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211
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Genome annotation – Proteins coding genes
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212
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Genome annotation – transcription factors
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213
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Gene predictions in Prokaryotes
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214
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Gene Predictions in Eukaryota
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217
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Comparison between mouse and human genome
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Week 13
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218
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Proteomics Types and Techniques
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219
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Characteristics of Human Proteome
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221
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Mapping of disease genes
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222
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Type of linkage analysis
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223
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Genome wide association studies
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224
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Association studies vs linkage studies
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230
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Microarray – Applications
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231
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Types of RNA and RNomics
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Week 14
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238
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Non coding RNA and X chromosome Silencing
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239
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RNA Induced Silencing Complex
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243
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Applications of siRNA
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246
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Small ribozymes and riboswitches
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247
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Pharmacogenetics and Pharmacogenomics
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248
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Pharmacogenomics principles and potentials
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