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BT732 : Genetics & Genomics

Course Overview

Course Synopsis

This is one of the course which introduces students to the fundamentals of genetic science through a basic study of the genetic material, what is the mode of inheritance, genetic and inherited diseases, concept of classical genetics, long way of Mendelian genetics to modern genetics, speciation, and evolutionary genetics, differentiation between microevolution and macroevolution. Moreover, advanced studies of genes, genomes and molecular genetics will also be touches in the later part of the course.

Course Learning Outcomes

Mendelian Genetics, Modern Genetics and Molecular Genetics

  • classical genetics, modern genetics, types of genetics, mode of inheritances, genetics diseases, genomics, Modern research and research techniques in genetics, molecular genetics. understanding of all these topics will enable you to understand the advanced courses in general genetics, molecular biology, cell biology, recombinant DNA technology and genomics

Course Calendar

What is Genetics1PPT
Sub discipilines of Genetics2PPT
Genetics Terminologies3PPT
Mendel''s law of Dominance4PPT
Monohybrid Cross and Dihybrid Cross5PPT
Mendel s’ law of Segregations6PPT
Mendel s’ law of Independent Assortment7PPT
Modern Genetics Concepts8PPT
Importance of Genetics9PPT
Heredity      Current Lesson10PPT
Genetic and Acquired Variation12PPT
Types of Variation- Continuous and Discontinuous Variation13PPT
Source of variation14PPT
Heredity and Variation in Mendel s’ work15PPT
Mendelian and Non-Mendelian Inheritance16PPT
Conclusions of Mendelian Inheritance17PPT
Exceptions to Mendelian Inheritance18PPT
Incomplete Dominance19PPT
Polygenic traits21PPT
Environmental Effects24PPT
What are Chromosomes25PPT
Cell, Nucleus and Chromosome26PPT
Chromosome Numbers in Different Species27PPT
Chromosomes in Prokaryotes and Eukaryotes28PPT
Salient features of Chromosomes29PPT
Size of Chromosomes30PPT
Types of Chromosomes31PPT
Centromere –Functions32PPT
Telomere Functions33PPT
Euchromatin and Heterochromatin34PPT
Staining and Banding Chromosomes35PPT
Assignment 1
Chromatin and Chromosomes37PPT
Higher Order Chromatin Folding38PPT
Prokaryotic Chromosomes41PPT
Sex Chromosomes and Sex determination42PPT
Salient features of DNA43PPT
Nucleotides – building blocks of DNA44PPT
Conformations of DNA45PPT
Chargaff Rule of Base Ratio46PPT
Giant Chromosomes47PPT
Lampbrush chromosome48PPT
Cell Division49PPT
Assignment 2
Cell Cycle50PPT
Unreplicated and Replicated Chromosomes52PPT
Prophase of Mitosis54PPT
Metaphase of Mitosis55PPT
Anaphase of Mitosis56PPT
Telophase of Mitosis57PPT
Mitotic Spindles59PPT
Somatic cells and Gametes60PPT
Homologous Chromosomes61PPT
Stages of Meiosis63PPT
Prophase I of Meiosis64PPT
Metaphase I of Meiosis65PPT
Anaphase I of Meiosis66PPT
Telophase I of Meiosis67PPT
Prophase II of Meiosis68PPT
Metaphase II of Meiosis69PPT
Anaphase II of Meiosis70PPT
Telophase II of Meiosis71PPT
Mitosis and Meiosis72PPT
Summary - Mitosis and Meiosis73PPT
Concept of Multiple Alleles74PPT
Multiple Alleles - our blood group75PPT
Blood groups and Transfusions76PPT
Multiple alleles effect in Drosophila77PPT
Correlation of Alleles and Genotypes78PPT
Polygenic Inheritance79PPT
Examples of Polygenic inheritance80PPT
What is Epistasis81PPT
Types of Epistasis82PPT
What is Epigenetics83PPT
Epigenetic Modifications84PPT
Chromosomal Aberrations85PPT
Karyotyping- international description86PPT
Defining Chromosome Location87PPT
Common Numerical Abnormalities88PPT
Polyploidy and Aneuploidy94PPT
Structural Abnormalities95PPT
Chromosomal Deletions97PPT
Chromosomal Insertions98PPT
Chromosomal Inversions99PPT
What is Mutation100PPT
Types of Mutation101PPT
Somatic and Germline Mutation102PPT
Forward, Reverse and Neutral Mutation103PPT
Loss of function, Gain of function104PPT
Spontaneous and Induced Mutation105PPT
Suppressor Mutation106PPT
Point Mutations107PPT
Silent Mutation108PPT
Missense Mutation109PPT
Nonsense Mutation110PPT
Additions Mutation111PPT
Inversion Mutation112PPT
Deletions Mutation113PPT
Mutation Nomenclature114PPT
Salient feature of Mutation Nomenclature115PPT
Mutation at DNA, RNA and Protein level116PPT
Mutation in Intronic Sequence117PPT
Specific changes in Sequence118PPT
What are Genetic Disorders119PPT
Inheritance Patterns of Genetic Disorders120PPT
Autosomal Recessive Inheritance121PPT
Special Assignment (In liue of Midterm exams)
Autosomal Dominant Inheritance122PPT
X-linked recessive inheritance123PPT
X-linked dominant inheritance124PPT
Maternal inheritance of mt DNA125PPT
Introduction to genomics126PPT
Functional Genomics127PPT
Structural genomics128PPT
Comparative genomics129PPT
Population Genomics130PPT
Genetics and Genomics132PPT
Genomics, Proteomics and metabolomics133PPT
Why sequence genomes134PPT
Genome characterization-technique used135PPT
Genome analysis steps136PPT
Benefits of Genomes research137PPT
Genes and Sizes of Genomes138PPT
Viral Genomes139PPT
Bacterial genomes140PPT
Yeast genome141PPT
Mitochondrial genome142PPT
Chloroplast genome (cpDNA)143PPT
Eukaryotic genomes144PPT
Genomes Comparison145PPT
Comparing distantly and closely related species146PPT
Anatomy and organization of genome147PPT
Gene anatomy148PPT
Prokaryotic gene and eukaryotic gene149PPT
Types of eukaryotic DNA150PPT
Duplicated genes and Pseudo genes151PPT
Repetitive DNA152PPT
Mobile DNA153PPT
Movement of transposons and retrotransposons154PPT
Transposons in Prokaryotes and Eukaryotes155PPT
Long terminal repeats156PPT
Genetic Variations158PPT
Gene families and Gene clusters159PPT
Types of Proteins and families160PPT
Gene densities161PPT
Genome evolution162PPT
Molecular Phylogenetic Analysis163PPT
Genes tree and species tree164PPT
Mitochondrial Genome Evolution165PPT
Genome evolution – Nucleotide substitution166PPT
Genome evolution CpG mutation rate167PPT
Genome evolution – Indels168PPT
Genome evolution Gene conversion169PPT
Genome evolution-Gene Duplications170PPT
Genome Evolution Exons Shuffling and duplications171PPT
Genome evolution – Recombination hotspots172PPT
Genome evolution double stranded break repair173PPT
Genome evolution chromosomal rearrangements174PPT
Gene expression mechanisms175PPT
Gene Expression and Genetic Switches176PPT
Inducible, repressible systems177PPT
Regulation of gene expression in Prokaryotes178PPT
Operon model of Prokaryotes179PPT
Eukaryotic gene expression180PPT
Control of gene expression in Eukaryotas181PPT
Cis-acting elements182PPT
Trans-acting elements183PPT
Gene expression and RNA interference184PPT
Assignment 3
Prokaryotic and eukaryotic gene expression -difference185PPT
Genome mapping186PPT
Genetic mapping of genomes187PPT
Genetic markers188PPT
Characteristics of genetic markers189PPT
DNA Markers190PPT
Applications of molecular markers191PPT
Physical mapping of Genomes192PPT
Cytogenetic mapping of genomes193PPT
FISH mapping of genomes194PPT
Restrictions mapping of Genomes195PPT
Radiation hybrid mapping of genomes196PPT
Clone contigs mapping of genomes197PPT
Generating sequence of genomes198PPT
Human Genome project199PPT
Human Genome project - Hierarchical shotgun sequencing200PPT
Human Genome project- Whole Genome shotgun sequencing201PPT
Human genome Characteristics (A)202PPT
Characteristics of our genome - B203PPT
Genes Functions204PPT
Genome browsers-UCSC205PPT
Genome browser- Ensemble206PPT
HapMap project207PPT
1000 genomes208PPT
Ethical and legal issues of Human Genome Project209PPT
Future Challenges of human genome project210PPT
Genome annotation – Proteins coding genes211PPT
Genome annotation – transcription factors212PPT
Gene predictions in Prokaryotes213PPT
Gene Predictions in Eukaryota214PPT
Arabidopsis Genome215PPT
Mouse genome216PPT
Comparison between mouse and human genome217PPT
Proteomics Types and Techniques218PPT
Characteristics of Human Proteome219PPT
Mapping of disease genes221PPT
Type of linkage analysis222PPT
Genome wide association studies223PPT
Association studies vs linkage studies224PPT
Types of microarray226PPT
Microarray Formats227PPT
Microarray – Applications230PPT
Types of RNA and RNomics231PPT
Non coding DNA232PPT
Non coding RNAs233PPT
Biogenesis of miRNA235PPT
Functions of miRNA236PPT
Mode of action miRNA237PPT
Non coding RNA and X chromosome Silencing238PPT
RNA Induced Silencing Complex239PPT
Dicer and Drosha241PPT
Design of siRNA242PPT
Applications of siRNA243PPT
Small ribozymes and riboswitches246PPT
Pharmacogenetics and Pharmacogenomics247PPT
Pharmacogenomics principles and potentials248PPT
Study of Omics249PPT
Final Examination
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