BT302 : Immunology

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Course Info

Course Category

Molecular Biology

Course Level

Undergraduate

Credit Hours

3

Pre-requisites

N/A

Instructor

Dr. Naureen and Dr. Ibrahim
PhD
NUST, Islamabad

Course Contents

1 Overview of Immune System 2 Infections vs Non-Infections 3 Role of Immune System 4 Types of Immune system 5 Components of Innate Immune System 6 Physical barriers of Innate Immune system 7 Secretory molecules of Innate Immune System 8 Cells of Innate Immune system 9 Phagocytosis 10 Intracellular killing 11 Complement System 12 Classical Pathway of Complement Activation 13 Alternate Pathway of Complement Activation 14 Lectin Pathway of Complement Activation 15 Effector Functions of Complement Proteins 16 Pathology related to Complement Proteins 17 Cells & Organs of the Immune System 18 Primary Lymphoid Organs 19 Secondary Lymphoid Organs 20 Cell of Immune Systems 21 Lymphoid Lineage of Immune Cells 22 Myeloid Lineage of Immune Cells 23 Lymphocyte Recirculation 24 Lymphocyte Migration & Localization 25 Clonal Selection of Lymphocyte 26 Control of Extracellular Pathogens 27 Control of Intracellular Pathogens 28 Properties of antibodies and antigens together with their structure, ... 29 Factors influencing Immunogenicity (Contribution of the Immunogen) 30 Factors influencing Immunogenicity (Contribution of the Biological System) 31 Factors influencing Immunogenicity (Method of Administration) 32 Chemical Nature of Immunogen 33 Types of Antigens 34 Superantigens 35 Hapten-Carrier Conjugate 36 Antigenic determinants recognized by Innate Immune System 37 Characteristics of Immunoglobulins 38 Basic Structure of Antibodies 39 Structure of the Variable Region 40 Antibodies Fragments Structure_Function 41 Classes of Antibodies 42 IgM_IgG Properties_Functions 43 IgA_IgE_IgD Properties_Functions 44 Types vs Sub-types of Antibodies 45 Antigen & Antibody Reactions 46 Factors Effecting on Antigen & Antibody Tests 47 Agglutination Reactions 48 Precipitation Reactions 49 Complement Fixation Tests 50 Enzyme Linked Immunosorbent Assay (ELISA) 51 Genetics of Antibody Structure & Diversity 52 General Characteristics of Antibody Response 53 Fate of Immunogen 54 Primary & Secondary Antibody Response 55 Kinetics of antibody response against T-dependent antigens 56 Kinetics of antibody response against T-independent antigens 57 Cellular Events during Antibody Response 58 Membrane & Secreted Antibodies 59 Expression of Immunoglobulin Genes & V(D)J Recombination 60 Somatic Recombination 61 Somatic Hypermutation 62 Role of Somatic Hypermutation in diversity of antibodies 63 V(D)J combinational Diversity 64 Regulation of V(D)J Recombination 65 Affinity Maturation 66 Class Switching or Class Switch Recombination 67 Antigen Processing & Presentation 68 Introduction to Antigen Processing & Presentation 69 Antigen Processing & Presentation of Endogenous antigens 70 Antigen Processing & Presentation of Exogenous antigens 71 Major Histocompatibility Complex (MHC) 72 Structure of Class I MHC molecules 73 Structure of Class II MHC molecules 74 Important Aspects of MHC 75 Role of MHC in Tissue Matching 76 Self MHC Restriction 77 Differences Between Monoclonal & Polyclonal Antibodies 78 Generation of Polyclonal Antibodies 79 Role of Adjuvants in Polyclonal Antibodies Production 80 Production of Monoclonal Antibodies 81 Hybridoma Formation 82 Usage of Monoclonal Antibodies 83 T-Lymphocyte Receptors, Maturation, Activation & Differentiation 84 Diversity of T-Cell Receptor (TCR) 85 CD3 complex Structure & Functions 86 Cell Surface Molecules involved in T-Cell & Other Interaction 87 Accessory Molecules 88 Co-Stimulatory Molecules for Activation & Maturation of T-Cells 89 B-Lymphocytes Receptors, Maturation, Activation & Differentiation 90 Antigens Processing by B-Cells 91 Nature of B-Cell Activation 92 B-Cell Receptor & Co-stimulation For Maturation 93 Role of CD40 in B-Cell Activation 94 Complement System_Introduction 95 Functions of Complement Proteins 96 Classical Pathway of Complement Activation_In Detail 97 Alternative Pathway of Complement Activation_In Detail 98 Lectin Pathway of Complement Activation_In Detail 99 Biological Active Products of Complement 100 Hypersensitivity 101 Classification of Hypersensitivity 102 Type I Hypersensitivity 103 Type II Hypersensitivity 104 Type III Hypersensitivity 105 Type IV Hypersensitivity 106 Comparison of different Type Hypersensitivity 107 Cytokines 108 Mechanism of acting of Cytokines 109 Categories of Cytokines 110 Cytokines of Innate Immune System 111 Cytokines of Adaptive Immune System 112 Cytokine Network 113 Immuno-Regulation by Cytokine 114 Resistance & Immune Response to Infectious diseases 115 Mechanisms of Immune Evasion 116 Immune Response against Extracellular Pathogens 117 Immune Response against Intracellular Pathogens 118 Cell Mediated Effector Response 119 Role of Cytotoxic T-Lymphocytes in Cell Mediated Immunity 120 Role of Helper T-Lymphocytes in Cell-Mediated Immunity 121 Role of NK cells in Cell Mediated Immunity 122 Antibody dependent Cellular Toxicity by Killer Cells 123 Lymphokine Activated Killer Cells in Cell Mediated Immunity 124 Leucocytes Migration & Inflammation 125 Role of Phagocytes in Inflammation 126 Chemotaxsis & Diapedesis of Leucocytes in Inflammation 127 Opsonization of Bacteria 128 Intracellular Killing by Leucocytes during Inflammation 129 Role of Cytokines in Inflammation 130 Inflammosomes in Inflammation 131 Acute vs Chronic Inflammation 132 Vaccines 133 Types of Vaccination 134 Natural vs Artificial Immunization 135 Artificial Passive Immunization 136 Artificial Active Immunization 137 Novel Vaccines 138 Role of Adjuvant in Vaccination 139 Adverse Effects of Vaccination 140 Tolerance, Diseases of Immune System-Autoimmunity 141 Immunological features of Tolerance 142 Mechanisms of Tolerance Induction 143 Tolerance to Tissues & Cells 144 Introduction to Autoimmunity 145 Etiology of Autoimmunity 146 General Classification of Autoimmunity 147 Diagnosis of Autoimmune Diseases 148 Treatment of Autoimmune Diseases 149 Transplantation Immunology 150 Transplantation Antigens 151 Induction of Immune Responses against Transplants 152 Immune Mechanisms of Graft Rejection 153 Prevention & Treatment of Graft Rejection 154 Transplantation of Blood Cells & Bone Marrow 155 Tumor Immunology 156 Tumor Associated Antigens 157 Tumor Associated Transplantation Antigens 158 Immunity Against Tumors 159 Escape of Tumor from Immuno-Surveillance 160 Use of Tumor Neo-antigens in Immuno-diagnosis & Immunotherapy 161 Immunodeficiency 162 Classification of Immunodeficiency 163 Acquired Immunodeficiency Syndrome (AIDS) 164 Immunodeficiency Disorders of T- Cells 165 Immunodeficiency Disorders of B- Cells 166 Immunodeficiency Defects of Phagocytic Cells 167 Immunodeficiency Defects of Complement System