Course Overview
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Course Synopsis
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This course will help post graduate students to understand the building blocks of life "The cells", how they made up of, cell constituents, cell interaction, cell processes, cell signaling and cells in system biology as a whole. Furthermore, it is best course for understanding molecules and units of life, biocatalysts, cell division/membranes, its origin and genetics in general. In the latter half of the course advanced topics are explained for better understanding of topics which includes cell junctions, Communicating/Gap Junctions, Plasmodesmata: Plant Gap Junctions, Cadherins, Cadherin link to actin, Cadherins & Development, Integrins, Integrin Cytoskeleton Interaction, GAG Organization, Filament Treadmilling, MAPs, IF Cross-linking, Actin Organization, Actin Organization 2, Severing Proteins, Molecular Motors, Force Generation, Kinesins & Dyneins, Intracellular Transport, Muscle Contraction, Anatomy of the Muscle Cell, Muscle Contraction Animation. After taking this course, students will be well familiar to the advances in cell biology but it will not be end of learning because there are many avenues to explore yet in this arena of knowledge.
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Course Learning Outcomes
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Advances in Cell Biology
- After taking this course, students will enable themselves to understand the advanced topics of cell biology cum road map for further advanced courses in the same subject or other related arena of cell/molecular biology, genetics and bioinformatics. this advanced course will tune the students to meditate on the latest trends in cell biology, practical aspects that how a student think about the research topics. what is going on in the real world in this subject of great concern in the context of personalized medicine and other areas of great concern in todays world. As far as the different topics are concerns, students will learn Cell Scaffolds, GAG Organization, Cell-Surface Proteoglycans, Controlled Degradation of ECM, The Cytoskeleton Introduction, Cell origin, Cell evolution, Cell interactions, Cell mobility, Cell processes and Cell membranes.
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Course Calendar
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Week 01
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1
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Introduction to Cell Biology
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4
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Polymers of Amino Acids
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7
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Carbohydrates: Sugar Polymers
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8
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Carbohydrates: Glycosidic linkages
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9
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Lipids: Nonpolar Hydrocarbons
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10
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Lipids: Saturated & Unsaturated
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11
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Nucleic Acids: DNA & RNA
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Week 02
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18
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The Endoplasmic Reticulum
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25
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Recognition and Adhesion
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26
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Transport across membranes
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Week 03
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36
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Comparison-(Mitosis-Meiosis)
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37
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Transcription regulation
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38
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Transcription regulation in E.Coli
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39
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Transcription Regulation in E.Coli 2
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40
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Transcription Regulation in Eukaryotes
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41
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Eukaryotic Transcription
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Week 04
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43
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Cell signalling and prehistoric world
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44
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The Instructions and the Design
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45
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The Modes and Principles
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46
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The Modes and Principles II
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47
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The Modes and Principles III
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49
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G protein linked receptor
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53
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Cell signalling and Us
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54
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Cell signaling and memory
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55
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Enzyme linked receptors
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Week 05
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56
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Enzyme linked receptors 2
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57
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Enzyme linked receptors 2 (Conti...)
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58
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RTK signalling gone wrong
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60
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PKB apoptosis inhibition
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62
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TGF-Beta receptor Family
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63
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Proteolysis Signaling Pathways
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Week 06
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72
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Acquired Immunological Tolerance
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81
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TH-2 B-Cell activation
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Week 07
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85
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The Alternative Pathway
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86
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Neoplastic Transformation
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87
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Growth promoting oncogenes
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88
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Growth promoting oncogenes Cyclins and CDKs
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89
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Growth promoting oncogenes Cyclins and CDKs (Conti..)
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93
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Protein Sorting Mechanism
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95
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Nuclear localization signals [NLSs] and transport
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Week 08
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98
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Control of import and export
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99
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Protein Transport into Mitochondria
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101
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ER Transport Introduction
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104
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Multipass Transmembrane Proteins
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107
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COPI the Retrieval Process
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111
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Organ repair via stem cell
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Week 09
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112
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Customized stem cells
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114
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Cytokines induced stem cell proliferation and differentiation
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115
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In-vitro organ/tissue fabrication
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116
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Introduction to the Advance Cell Biology
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118
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Communicating/Gap Junctions
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119
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Plasmodesmata: Plant Gap Junctions
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121
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The Anatomy of Occluding Junctions
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Week 10
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126
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Cadherin link to actin
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127
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Cadherins & Development
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129
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Transient Cell-Cell Adhesions
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130
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Selectins & cytoskeleton
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131
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Ca2+-independent Cell-Cell Adhesion
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134
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Integrin Cytoskeleton Interaction
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135
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Anchor Proteins Introduction
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136
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Anchor Proteins Detailed View
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139
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Integrins & Cell Survival
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Week 11
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140
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Extracellular Matrix(ECM)
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141
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Glycosaminoglycan (GAG)
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142
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Hyaluronan (hyaluronic acid or hyaluronate)
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143
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Proteoglycans & Glycoproteins
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146
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Cell-Surface Proteoglycans
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151
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Fibril Associated Collagen (FAC)
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152
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Cell Organize Collagen Fibrils
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Week 12
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156
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Basal Lamina (Basement Membrane)
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157
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Basal Lamina Additional Functions
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158
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ECM: Cell Shape, Survival & Proliferation
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159
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Controlled Degradation of ECM
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160
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The Cytoskeleton Introduction 1
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161
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The Cytoskeleton Introduction 2
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162
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The Cytoskeleton Introduction 3
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164
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Cytoskeletal Polymer Nucleation
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Week 13
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168
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Filament Treadmilling
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169
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Treadmilling Animation
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171
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Dynamic Instability Animation
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172
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Tubulin & Actin Isoforms
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173
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Intermediate Filament
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179
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Actin Filament Nucleation
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180
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Actin Filament Elongation
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181
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Tropomyosin & Cofilin
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Week 14
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192
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Intracellular transport
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194
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Anatomy of the muscle cell
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195
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Muscle Contraction animation
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