Course Overview
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Course Synopsis
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This course is designed to develop understanding of the students to the fundamental concepts of fermentation technology, microbial growth kinetics, designing of bioreactors and their control systems, aeration and agitation, scale up and scale down studies, different fermentation media and their sterilization and product recovery. This course will enable the students to get sufficient knowledge about the subject to carry out research in the same field.
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Course Learning Outcomes
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After the successful completion of the course, students will be able to
- Understand and comprehend the scope of Fermentation Technology.
- Understand the fundamentals of microbial growth kinetics
- Design bioreactors and their control systems
- Design aeration and agitation system for bioreactors
- Carry out scale up and scale down studies
- Formulate media for industrial fermentations
- Understand and apply different sterilization modes in a fermentation process
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Course Calendar
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Week 01
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1
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Overview of Fermentation Technology-1
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2
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Overview of Fermentation Technology-2
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4
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Types of Fermentation on the basis of oxygen need
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5
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Types of Fermentation on the basis of Moisture
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6
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Types of Fermentation on the basis of Production Scale
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7
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Range of Fermentation Products
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8
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Range of Fermentation Products 2
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9
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Range of Fermentation Products 3
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10
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Range of Fermentation Products 4
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11
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Range of Fermentation Products 5
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12
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Range of Fermentation Products 6
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Week 02
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13
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Types of Fermentation on the basis of Process
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14
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Types of Fermentation on the basis of State of Mixing
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15
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Types of Fermentation on the basis of Product and Organisms
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16
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Organization of Fermentation Process
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17
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Microbial Growth kinetics: Introduction
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18
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Microbial Growth kinetics: Methods to calculate/measure growth
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19
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Microbial Growth kinetics: Batch Culture 1
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20
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Microbial Growth kinetics: Batch Culture 2
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21
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Microbial Growth Kinetics: Batch Culture 3
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22
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Microbial Growth Kinetics: Batch Culture 4
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23
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Microbial Growth Kinetics: Batch Culture 5
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Week 03
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24
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Microbial Growth Kinetics: Batch Culture 6
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25
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Microbial Growth Kinetics: Batch Culture 7
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26
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Microbial Growth Kinetics: Fed Batch Culture I
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27
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Microbial Growth Kinetics: Fed Batch Culture 2
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28
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Microbial Growth Kinetics: Fed Batch Culture 3
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29
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Microbial Growth Kinetics: Fed Batch Culture 4
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30
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Microbial Growth Kinetics: Fed Batch Culture 5
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31
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Microbial Growth Kinetics: Fed Batch Culture 6
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32
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Microbial Growth Kinetics: Continuous Culture 1
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33
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Microbial Growth Kinetics: Continuous Culture 2
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34
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Microbial Growth Kinetics: Continuous Culture 3
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35
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Microbial Growth Kinetics: Continuous Culture 4
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Week 04
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36
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Microbial Growth Kinetics Principles of Growth in Continuous system
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37
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Microbial Growth Kinetics Calculation of Growth Yield in Chemostat
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41
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Fermenter Design. General requirements of Fermenters
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42
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Fermenter Design Aseptic operation and containment
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43
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Fermenter design: Aseptic Operation and Containment 2
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44
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Fermenter Design: General Introduction of a Fermenter
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45
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Fermenter Design Basic Design of a Stirred Fermenter
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46
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Fermenter Design: Body Construction
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47
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Fermenter Design: With Multi Impeller
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Week 05
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48
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Fermenter Design: Construction materials
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49
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Fermenter Design: Pilot Scale and Industrial Scale Fermenters
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50
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Fermenter Design: Grading Quality of construction material
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51
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Fermenter Design Seals and O rings
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52
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Fermenter Design Basic Features of a Stirred Tank Bioreactor. Agitation System 1
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53
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Fermenter Design: Basic Features of a Stirred Tank Bioreactor. Agitation System 2
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54
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Fermenter Design: Agitator Design and Operation 1
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55
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Fermenter Design: Agitator Design and Operation 2
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56
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Fermenter Design: Agitator Design and Operation 3
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57
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Fermenter Design: Agitator Design and Operation 4
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58
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Fermenter Design: Agitator Design and Operation: Axial flow Impellers 1
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59
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Fermenter Design: Agitator Design and Operation: Axial flow Impellers 2
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Week 06
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60
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Fermenter Design: Temperature Control System 1
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61
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Fermenter Design: Temperature Control System 2
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62
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Fermenter Design Oxygen Delivery System
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63
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Fermenter Design Oxygen Delivery System Air sterilization system 1
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64
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Fermenter Design Oxygen Delivery System Air sterilization system 2
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65
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Fermenter Design Oxygen Delivery System Air sterilization system 3
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66
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Fermenter Design: Oxygen Delivery System: Sparger
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67
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Fermenter Design: Oxygen Delivery System: Air Flow System
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68
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Fermenter Design: Fermenter Design: Foam Control System 1
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69
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Fermenter Design: Fermenter Design: Foam Control System 2
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70
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Fermenter Design: Fermenter Design: Foam Control System 3
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71
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Fermenter Design: pH Control System 1
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72
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Fermenter Design: pH Control System 2
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Week 07
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73
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Fermenter Design: Cleaning, Sterilization and sampling Facilities
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74
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Media for industrial Fermentation: Introduction 1
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75
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Media for Industrial Fermentations: Introduction 2
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76
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Media for industrial fermentation: Introduction 3
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77
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Media for industrial fermentation: Introduction 4
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78
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Media for industrial fermentations: Introduction 5
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79
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Media for industrial fermentations: Medium formulation 1
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80
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Media formulation for industrial fermentations: Medium formulation 2
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81
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Media for industrial fermentations: Medium formulation 3
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82
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Media for industrial fermentations: Medium components
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83
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Media for industrial fermentations: Carbon sources
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84
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Media for industrial fermentations - Example of commonly used carbon sources 1
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Week 08
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85
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Media for industrial fermentations -Examples of commonly used carbon sources -2
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86
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Media for industrial fermentations- Examples of commonly used carbon sources -3
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87
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Media for industrial fermentations -Nitrogen sources
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88
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Media for industrial fermentations- Examples of commonly used nitrogen sources
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89
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Media for industrial fermentations - Mineral 1
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90
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Media for industrial fermentations: Mineral 2
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91
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Media for industrial fermentations -Chelators
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92
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Media for industrial fermentations-Growth factor
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93
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Media for industrial fermentations -Buffers
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94
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Media for industrial fermentation -Precursors
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95
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Media for industrial fermentations- Inhibitors
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96
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Media for industrial fermentation- Inducers 1
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Week 09
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97
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Media for industrial fermentations - Inducers 2
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98
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Media for industrial fermentations - oxygen requirements, trace elements, pH and osmolality
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99
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Media for industrial fermentation- Antifoams 1
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100
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Media for industrial fermentation-Antifoams 2
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101
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Media for Industrial Fermentations Antifoams 3
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102
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Media for Industrial Fermentations Medium Optimization
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103
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Media for Industrial Fermentations. Medium optimization Plackett-Burman Design 1
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104
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Media for Industrial fermentations. Medium Optimization Plackett-Burman Design 2
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105
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Aeration and Agitation Introduction 1
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106
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Aeration and Agitation Introduction 2
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107
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Aeration and Agitation Oxygen Requirements of Industrial fermentations 1
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108
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Aeration and Agitation Oxygen Requirements of Industrial fermentation 2
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Week 10
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109
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Aeration and Agitation Henry Law and Oxygen Supply
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110
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Aeration and Agitation Oxygen Transfer Process 1
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111
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Aeration and Agitation Oxygen Transfer Process 2
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112
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Aeration and Agitation Determination of KLa Values Sulphite oxidation Technique
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113
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Aeration and Agitation Determination of KLa Values Gassing out Techniques 1
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114
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Aeration and Agitation Determination of KLa Values Gassing out Techniques 2
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115
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Aeration and Agitation Determination of KLa Values The oxygen balance Technique
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116
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Sterilization Introduction 1
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117
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Sterilization Introduction 2
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118
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Medium Sterilization 1
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119
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Medium Sterilization 2
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120
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Medium Sterilization 3
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Week 11
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121
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Medium Sterilization 4
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122
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Medium Sterilization 5
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123
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Medium Sterilization 6
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124
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Medium Sterilization 7
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125
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Medium Sterilization The design of batch sterilization processes
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126
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Medium sterilization. Calculation of DEL factor during heating and cooling
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127
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Medium sterilization Calculation of holding time at constant temperature
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128
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Medium Sterilization Richards Rapid method for the designing of sterilization cycles
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129
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Medium Sterilization The scale up of batch sterilization processes
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130
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Medium Sterilization Methods of Batch Sterilization
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131
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Medium Sterilization The design of continuous sterilization processes 1
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Week 12
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132
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Medium Sterilization The design of continuous sterilization processes 2
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133
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Medium Sterilization The design of continuous sterilization processes 3
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134
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Sterilization of the Fermenter, Feeds and of Liquid Wastes
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136
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Filter Sterilization of Fermentation Media
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137
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Filter Sterilization of Fermentation air
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138
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Sterilization of Fermenter exhaust air
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139
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Process Organism: Selection criteria
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140
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Process Organism: Collection of industrially important microorganisms-1
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141
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Process Organism: Collection of industrially important microorganisms-2
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142
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Process Organism: Collection of industrially important microorganisms-3
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143
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Process Organism: Screening methods for isolated microbes
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Week 13
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144
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Process Organism: Identification of microorganisms
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145
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Process Organism: Storage/Preservation of microbial cultures
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146
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Process Organism: Improvement of industrially important microorganisms-1
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147
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Process Organism: Improvement of industrially important microorganisms-2
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148
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Process Organism: Improvement of industrially important microorganisms-3
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149
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Process Organism: Mutant Selection-1
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150
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Process Organism: Development of inocula for industrial fermentation: Introduction-1
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151
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Process Organism: Development of inocula for industrial fermentation: Introduction-2
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152
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Process Organism: Criteria for the transfer of inoculum
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153
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Process Organism: Development of inocula (Examples)
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154
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Recovery and Purification of Fermentation Products-1
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155
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Recovery and Purification of Fermentation Products-2
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156
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Recovery and Purification of Fermentation Products-3
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Week 14
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157
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Recovery and Purification of Fermentation Products-4
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158
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Recovery and Purification of Fermentation Products-5
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164
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Fermentation Economics
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165
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Practical Demonstration
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